Keyhole lobectomy in a British trial of 503 patients meant less pain, fewer complications and a median stay of four days, and small tumors at the edge of the lung now need only a segment removed. This page explains the tests before surgery, when lobectomy or segmentectomy fits, how keyhole, robotic and open surgery compare, which treatment comes before and after, and how two to three weeks in Istanbul are planned.
About This Department
Surgical Oncology
A lobectomy removes the lobe of the lung that holds the tumor, together with its lymph nodes. After keyhole surgery, the median hospital stay in a large trial was four days.
Lung lobectomy remains the standard operation for early lung cancer that has not spread beyond the chest. The right lung has three lobes and the left has two, and the lobes that remain expand to fill the space. This page explains the tests before surgery, when a smaller segmentectomy is enough, how keyhole, robotic and open surgery compare, what treatment comes before and after, and what to send for a free review of your scans.
4 days
Median hospital stay after keyhole lobectomy, against 5 after open surgery, in the VIOLET trial
94.3%
Five-year survival after segmentectomy for tumors of 2 cm or less in the JCOG0802 trial, against 91.1% after lobectomy
65.4%
Five-year survival with nivolumab and chemotherapy before surgery, against 55.0% with chemotherapy alone
The right lung has three lobes and the left lung has two.
The surgeon divides the artery, vein and airway of one lobe and removes it whole.
Lymph nodes from the root of the lung and the center of the chest come out with it. Node clearance decides the stage. A review of national data found that only 12.6 percent of segmentectomies met all three quality standards for lymph node evaluation, so the operation note should list every node station sampled.
Lobectomy also treats some conditions that are not cancer, such as a lobe destroyed by bronchiectasis or old infection, and carcinoid tumors.
Lobectomy or segmentectomy
For small tumors at the edge of the lung, removing one or more segments can suffice.
Two randomized trials changed practice. In JCOG0802, 1,106 patients in Japan with tumors of 2 centimeters or less, mostly solid on thin-slice CT, were randomized to segmentectomy or lobectomy. Five-year survival reached 94.3 percent after segmentectomy and 91.1 percent after lobectomy, the first trial to show a survival gain for the smaller operation, and lung function at one year was 3.5 percent better. Local recurrence rose in exchange, 10.5 against 5.4 percent. In CALGB 140503, 697 patients with tumors of the same size did as well after a smaller resection as after lobectomy, and patients older than 75 had the same rates of serious complications and death at 90 days as younger ones. Margins count as much as size. A segmentectomy also leaves more lung for a second operation if a new cancer appears years later, which matters because anyone who has had one lung cancer carries a raised risk of another.
Lobectomy stays the choice for larger or central tumors, tumors with lymph node spread and tumors that look solid and aggressive on CT.
This table scrolls sideways on a narrow screen. Swipe or drag to see every column.
Segmentectomy against lobectomy in JCOG0802
Measure
Segmentectomy
Lobectomy
Five-year survival
94.3%
91.1%
Five-year survival free of relapse
88.0%
87.9%
Local recurrence
10.5%
5.4%
Complications of grade 2 or worse
27%
26%
Deaths within 90 days
None
None
Keyhole, robotic or open surgery
1
Anesthesia
General anesthesia with a breathing tube that lets one lung rest while the other breathes.
2
Access
Keyhole surgery uses one to four small cuts with a camera and no rib spreading, while open surgery uses one longer cut between the ribs.
3
Removing the lobe
Staplers divide the vessels and the airway, and the lobe leaves the chest in a bag.
4
Drain
One chest drain.
In the VIOLET trial, 503 patients at nine British hospitals were randomized to keyhole or open lobectomy. Five weeks after surgery, physical function was better after keyhole surgery, pain on the second day was lower, and the median hospital stay was four days against five, while complications before discharge fell by a quarter, a relative risk of 0.74, and survival stayed similar. Patients simply recovered faster. Robotic surgery works through the same small cuts, with the surgeon moving the instruments from a console. Across four randomized trials with 548 patients, robotic and video-assisted lobectomy gave the same complication rate, hospital stay, lymph node yield and survival.
On a phone, slide this table sideways to read all of its columns.
Keyhole against open lobectomy in VIOLET
Measure
Finding
Physical function at five weeks
Better after keyhole surgery
Pain on day two
Lower after keyhole surgery
Median hospital stay
4 days against 5
Complications before discharge
Fewer, relative risk 0.74
Survival
Similar
Some cases need it. Open surgery remains the route for large central tumors and for operations that rebuild an airway or a blood vessel.
Tests before surgery
The surgeon needs to know how much lung you can spare and whether the cancer has spread.
Breathing tests, including FEV1 and the diffusing capacity of the lung
A PET-CT scan of the whole body
Sampling of chest lymph nodes through a bronchoscope when scans show enlarged nodes
A heart check and, for borderline lung function, an exercise test
Predicted lung function after surgery comes from these tests and the number of segments in the lobe to be removed. Simple arithmetic, done before any date is set.
Treatment before surgery
Stage IB to IIIA tumors qualify for immunotherapy with chemotherapy before surgery.
Three cycles come first, and surgery follows within weeks.
In CheckMate 816, 358 patients with stage IB to IIIA lung cancer received three cycles of chemotherapy with or without the immunotherapy drug nivolumab before surgery. Five-year survival reached 65.4 percent with the combination and 55.0 percent with chemotherapy alone, a hazard ratio for death of 0.72. Ten points. Patients whose tumor had disappeared completely under the microscope at surgery reached 95.3 percent. The tumor board makes the call for each patient, because tumors with certain gene changes, such as EGFR or ALK, follow a different path with targeted tablets, and very small tumors go straight to surgery.
Drag sideways on a narrow screen to see the whole table.
Nivolumab with chemotherapy before surgery in CheckMate 816
Measure
Nivolumab plus chemotherapy
Chemotherapy alone
Patients
179
179
Five-year survival
65.4%
55.0%
Hazard ratio for death
0.72
Reference
Risks and how they are lowered
An air leak from the lung surface that keeps the drain in longer
Pneumonia or collapse of part of the remaining lung
An irregular heart rhythm in the first days
Bleeding, rarely needing a return to the operating room
Pain or numbness along the scar
Exercise before surgery
Across 29 randomized trials with 2,900 patients, exercise training before lung cancer surgery cut lung complications by more than half, a relative risk of 0.42, and shortened the hospital stay by 2.22 days. Walking, stair climbing and breathing exercises in the weeks before the trip all count. Start now. Stopping smoking helps too.
After surgery
You sit in a chair and walk on the day after surgery.
Pathology decides what comes next.
1
Drain out
When the lung has sealed and fluid output is low.
2
Pathology
Stage, margins, node count and gene tests arrive within ten days.
3
Treatment after surgery
For EGFR-mutated tumors, osimertinib tablets after surgery raised five-year survival from 78 to 88 percent in the ADAURA trial of 682 patients, and your oncologist at home can prescribe them.
4
Follow-up
CT every six months for two years, then yearly.
Your time in Istanbul
One published Istanbul package for lobectomy, at Hisar Intercontinental, lists 11 nights in hospital, one of them in intensive care, with airfare excluded.
That budget runs long. The median after keyhole surgery in VIOLET was four days. The listing advises 20 days in Turkey after the operation, and we plan two to three weeks, because the flight home waits until a chest X-ray confirms the lung has fully expanded and the drain site has closed.
Day one, breathing tests, CT and blood tests
Day two, tumor board review and consent
Day three, surgery
Ward days, drain care, walking and physiotherapy
Before the flight, a chest X-ray, the pathology report and a treatment plan for home
We shape every plan around one patient. Your coordinator answers the first WhatsApp message, organizes each step of the trip and keeps the same number for your questions after you have flown back home. We cover English, Arabic, French, Russian, Serbian, Romanian and Spanish within the team, and an interpreter joins for other languages. A relative may sleep on the companion bed in your room. Airport pickup, a nearby hotel and transport to every appointment run through the international patients office. On request, a female surgeon operates when the rota permits. Meals come halal, vegetarian or diabetic. A prayer room sits on site. Expect the visa invitation letter ten days ahead of travel. Lifting a suitcase strains a fresh chest wound, so help with luggage and a wheelchair are arranged at both airports, and on the plane a short walk down the aisle every hour lowers the risk of clots in the legs. After you return, the pathology report and a written treatment plan in English go to your oncologist. Video calls with the surgeon cover your recovery and the first scans.
Call us the same day for fever, worsening breathlessness, coughing up blood, swelling around the scar, or calf or chest pain.
What the cost depends on
Cost depends on lobectomy or segmentectomy, keyhole, robotic or open surgery, treatment before surgery, the nights on the ward and in intensive care, how long the drain stays and whether a prolonged air leak keeps you in hospital longer. A firm figure follows the free review of your scans and reports. It comes in writing.
The written quote names every item it covers, including the tests in the first two days.
Lung lobectomy FAQ
Can I live normally with one lobe removed?
Yes, for most people. The remaining lobes take over, and in JCOG0802 lung function a year after lobectomy was only 3.5 percent lower than after the smaller segmentectomy.
How long does the operation take?
Two to four hours, longer when lymph nodes are stuck to vessels or the lobe has old scarring.
When can I fly home?
Once the drain is out and a chest X-ray shows the lung fully expanded, the surgeon clears you to fly.
Will I need chemotherapy?
The final stage decides. Stage II and III tumors receive treatment after surgery, and EGFR-mutated tumors receive osimertinib.
What should I send for a free review?
CT and PET-CT images, breathing test results, any biopsy report with gene tests, a list of medications and your smoking history. A thoracic surgeon replies with whether surgery suits you, the type of operation and the expected stay, at no charge and with no obligation to travel.
Send the scan images on a download link or disc, since reports alone do not show where the tumor sits.
References
Saji H, Okada M, Tsuboi M, et al. Segmentectomy versus lobectomy in small-sized peripheral non-small-cell lung cancer (JCOG0802/WJOG4607L): a multicentre, open-label, phase 3, randomised, controlled, non-inferiority trial. Lancet. 2022;399(10335):1607-1617.
Ganti AK, Damman B, Wang X, Stinchcombe TE, Altorki N. Outcomes based on age in CALGB 140503 (Alliance): lobar versus sublobar resection for peripheral stage IA non-small cell lung cancer. Clin Lung Cancer. 2026;27(7):42-49.
Lim E, Harris RA, McKeon HE, et al. Impact of video-assisted thoracoscopic lobectomy versus open lobectomy for lung cancer on recovery assessed using self-reported physical function: VIOLET RCT. Health Technol Assess. 2022;26(48):1-162.
Mirza W, Javid A, Khan ME, et al. Robotic-assisted vs video-assisted thoracoscopic lobectomy for non-small cell lung cancer: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials on surgical quality, perioperative, and oncologic outcomes. J Robot Surg. 2025;19(1):651.
Forde PM, Spicer JD, Provencio M, et al. Overall survival with neoadjuvant nivolumab plus chemotherapy in lung cancer. N Engl J Med. 2025;393(8):741-752.
Tsuboi M, Herbst RS, John T, et al. Overall survival with osimertinib in resected EGFR-mutated NSCLC. N Engl J Med. 2023;389(2):137-147.
Chen QQ, Liang Y, Xu Y, Zhao LF. Preoperative exercise-based prehabilitation for reducing postoperative pulmonary complications after lung cancer surgery: a systematic review and meta-analysis. Front Med (Lausanne). 2026;13:1899789.
Bazarbaev A, Androutsopoulou V, Zotos PA, et al. Nodal evaluation as the arbiter of oncologic equivalence: reassessing segmentectomy after CALGB 140503 and JCOG0802. Front Oncol. 2026;16:1986814.
Editor's note
Written by the Biruni Hospital medical editorial team. Reviewed by Prof. Dr. Özcan YILDIZ, Medical Oncology.