Whether you carry a BRCA mutation, have cancer in one breast or in both, bilateral mastectomy removes both breasts in one operation, and how much it helps depends on which of those three paths brought you to it.
About This Department
Breast Oncology
Removing both breasts lowers one risk sharply. Whether that helps you depends on why you are considering it.
In BRCA carriers, bilateral prophylactic mastectomy reduced breast cancer risk by about 90 percent. For a healthy breast removed alongside a cancer, a Cochrane review found too little evidence of a survival gain.
About 90%
Breast cancer risk reduction in BRCA carriers after bilateral mastectomy
72% and 69%
Breast cancer risk by age 80 for BRCA1 and BRCA2 carriers
10 to 14 days
Usual stay in Istanbul with implant reconstruction
Free
Review of your imaging and genetic results
Free consultation
The review costs nothing and carries no obligation. Send your mammogram, ultrasound and MRI reports, any biopsy result and genetic test results, and a breast surgeon will tell you whether a bilateral mastectomy fits your situation, which type and reconstruction suit you, and how long to plan for. A coordinator replies in your own language, and you can ask for a female surgeon.
You may have cancer in one breast and be weighing whether to remove the other too, or carry a BRCA mutation and want to lower a risk you have watched affect your family, or have cancer found in both breasts at once. Bilateral mastectomy removes both breasts in one operation, with or without the nipples and skin, and is often combined with breast reconstruction under the same anesthetic. Below you will find the three situations that lead to it, what the numbers say about inherited risk, how much risk the operation removes and what it does not change, the alternatives, the types of mastectomy and reconstruction, the complication figures, the recovery, how long to stay in Istanbul, and the follow-up at home.
Three reasons for a bilateral mastectomy
The reason shapes everything else. Women come to this operation by one of three routes.
Cancer found in both breasts at once.
Cancer in one breast, with a choice to remove the healthy one too.
No cancer, but a BRCA mutation or another high inherited risk.
When cancer is found in both breasts at the same time, removing both is treatment, and the decision follows the same rules as any mastectomy for cancer. When cancer is in one breast only, removing the healthy breast as well is a choice called contralateral prophylactic mastectomy, and its value depends heavily on your inherited risk, your age and your own priorities, since for most women without a high-risk gene the chance of a new cancer in the other breast is low. When there is no cancer at all but a BRCA1 or BRCA2 mutation or a similar high-risk finding, a bilateral risk-reducing mastectomy is preventive surgery, planned without any time pressure, and many women combine it with reconstruction at the same sitting. Each of these paths deserves its own conversation with a breast surgeon and, for the second and third, with a genetic counselor, and each path changes what the operation can and cannot do for you.
The three paths side by side
Why the path matters for surgery
Lymph node surgery, radiotherapy afterward and the timing of reconstruction all depend on whether cancer is present and where, so the same operation can mean a short stay for one woman and months of treatment for another.
This table scrolls sideways on a narrow screen. Swipe or drag to see every column.
The three paths to a bilateral mastectomy
Situation
Main purpose
Lymph node surgery
Cancer in both breasts
Treating both cancers
On both sides as needed
Cancer in one breast, healthy breast removed too
Treating one cancer and preventing a new one in the other breast
On the cancer side only
No cancer, high inherited risk
Preventing breast cancer
Not routinely
How high inherited risk really is
A prospective study of nearly 10,000 women carrying BRCA1 or BRCA2 mutations, published in JAMA in 2017, measured the risk directly.
Inherited risk is the deciding number.
Ask for genetic testing first
A family with breast cancer before fifty, ovarian cancer, male breast cancer, or several relatives on one side. The result changes the decision more than any other single fact.
On a phone, slide the table sideways to see both gene columns.
Cumulative breast cancer risk in BRCA carriers
Risk
BRCA1
BRCA2
Breast cancer by age 80
72 percent
69 percent
Cancer in the other breast within 20 years of a first breast cancer
40 percent
26 percent
Ovarian cancer by age 80
44 percent
17 percent
Risk rose with the number of close relatives affected.
Other genes that raise risk
PALB2, TP53, PTEN and CDH1 also raise breast cancer risk, some of them close to BRCA levels, and a genetic counselor explains what a result in one of them means for surgery.
What removing both breasts achieves
For BRCA carriers without cancer, the benefit is large.
What the PROSE study compared
It followed 483 women with BRCA1 or BRCA2 mutations. Breast cancer developed in 2 of 105 women after bilateral prophylactic mastectomy, 1.9 percent, against 184 of 378 matched carriers who kept their breasts, 48.7 percent, over a mean of 6.4 years.
That is a reduction of roughly 90 percent, rising to 95 percent in women who had also had their ovaries removed.
Risk falls sharply. It does not reach zero.
What the operation does not change
A small amount of breast tissue always remains under the skin and in the armpit, so a new lump still needs checking, and the risk of a cancer already diagnosed coming back is unchanged.
For a healthy breast removed alongside a cancer, the picture changes. A Cochrane review of 61 observational studies and more than 15,000 women found that this lowers the chance of cancer in the other breast, but found too little evidence that it helps women live longer, because the main threat to life remains the cancer already diagnosed. The same review found that most women were satisfied with their decision and worried less about cancer, while satisfaction with body image and sexual feelings fell for some. Unplanned further operations ranged from 4 percent in women without reconstruction to 64 percent in some series with reconstruction, which is why the reconstruction choice weighs as much as the mastectomy itself and deserves the same care when you plan the operation with your surgeon and decide between implants, your own tissue or a flat closure. Bias matters. The reviewers noted that younger and healthier women were more likely to choose the extra surgery, which can make its survival figures look better than the operation deserves.
Options other than surgery
Not every high-risk woman chooses a mastectomy, and each alternative is a real option.
1
Intensive screening
A yearly breast MRI with a mammogram, starting young for BRCA carriers, finds most cancers early without removing the breasts.
2
Risk-reducing medicines
Tablets such as tamoxifen lower the risk for some women over five years of treatment.
3
Removing the ovaries
For BRCA carriers after childbearing, this cuts the high ovarian cancer risk that comes with the gene.
Signs it may be time
A BRCA1, BRCA2 or similar high-risk result, a strong family history confirmed by a genetic counselor, cancer in both breasts, or anxiety about screening that has become hard to live with after full counseling.
Talk to us first
An average or modestly raised risk, a decision made in the first shock of a diagnosis, smoking or diabetes that raise wound risk, or a wish driven mainly by fear of radiotherapy, which mastectomy does not always avoid.
Types of mastectomy and reconstruction
Skin and nipple can stay in many cases.
Total mastectomy. Breast tissue, nipple and much of the skin removed.
Skin-sparing mastectomy. The skin envelope kept for reconstruction.
Nipple-sparing mastectomy. Skin and nipple kept when no cancer lies near the nipple.
Reconstruction can follow in the same operation, with implants or with your own tissue from the abdomen or back, or later once other treatment is over, and some women choose to stay flat with a smooth chest wall closure. Our breast reconstruction page covers those options in detail.
Choosing to stay flat
Some women prefer no reconstruction. A careful flat closure removes extra skin so the chest lies smooth, and a prosthesis in the bra remains an option on any day.
Getting ready
1
Genetic counseling
Testing and a personal risk estimate before deciding.
2
Imaging both breasts
An MRI or mammogram of both breasts close to the date of surgery, so that a hidden cancer in the breast thought to be healthy is not missed and the plan for that side can change if one is found.
3
Reconstruction plan
Chosen before the day.
4
No smoking
Smoking raises the risk of skin and nipple loss after nipple-sparing surgery, so stopping weeks ahead protects the result.
Complications and how they are managed
Two breasts mean two wounds. A national database study of 9,319 women found higher odds of complications when one breast was removed for cancer and the other prophylactically than when both were removed preventively, a difference linked to the lymph node surgery on the cancer side. In a series of 434 nipple-sparing mastectomies with implant reconstruction, 11 percent needed a further operation for a complication within 30 days, with no difference between one breast and two.
Fluid collection and bleeding
Drains in the first days, and aspiration of fluid in clinic if it gathers later.
Skin or nipple loss
Mainly after nipple-sparing surgery in smokers. Dressings or a small revision answer most cases.
Implant problems
Infection, exposure or a firm capsule may need further surgery.
Numbness
The chest skin and nipples lose most feeling, and this is largely permanent.
The recovery
Arm exercises start the next day.
Drains stay for one to two weeks, and you sleep on your back with a supportive bra or binder. Light daily activity resumes within days, desk work in two to four weeks, and lifting and driving wait for drains to come out and the surgeon to clear them, longer after tissue reconstruction. The emotional recovery runs on its own timetable. Many women feel relief alongside grief for what was lost, and talking with a counselor or with others who have been through it helps. Looking at the chest for the first time is easier with a nurse or a partner present, and the team plans that moment rather than leaving it to chance at the first dressing change. Shoulder stiffness is common in the first weeks, so the physiotherapist teaches a short set of arm lifts and wall climbs to do several times a day until full movement returns, which for most women takes four to six weeks.
How long to stay in Istanbul
Plan for two weeks with reconstruction.
Published mastectomy packages in Istanbul list two days in hospital and a seven-day stay in Turkey. With immediate implant reconstruction on both sides the stay runs to ten to fourteen days, which leaves time for the drains to come out, the wounds to be checked by the surgeon and the first arm exercises to be learned before flying, and tissue reconstruction needs longer still.
What decides the cost
One or both sides, the type of mastectomy, reconstruction and its method, lymph node surgery, nights in hospital and genetic testing set most of the figure.
Published packages list the surgeon consultation, preoperative tests, general anesthesia, the mastectomy, hospital stay, follow-up examinations and airport transfers, and some add sentinel node examination, a private room or an implant. Hotel nights often sit outside them.
A quote you can compare names both sides, the reconstruction and the stay, and that figure comes only from a breast surgeon reading your imaging and genetic results.
The review costs nothing.
Arranging the trip
A first WhatsApp message reaches a coordinator who stays with you through surgery and after you fly home. You can ask for a female surgeon in that first message. English, Arabic, French, Russian, Serbian, Romanian and Spanish are spoken, with an interpreter for other languages, a companion sleeps in your room on the companion bed, and the international office books a hotel, sends the visa invitation letter ten days before travel and arranges transfers. Halal, vegetarian and diabetic meals and a prayer room are available.
Once you are back home
After a preventive mastectomy, routine screening of the chest is not needed for most women, though any new lump is checked. After cancer, follow-up continues with your oncologist, and BRCA carriers plan for ovarian risk with a gynecologist.
Fever, spreading redness, a wound that opens, a swollen tense breast, or a darkening of the nipple or skin. Each needs a doctor the same day.
Bilateral mastectomy FAQ
How much does a bilateral mastectomy reduce breast cancer risk?
In BRCA carriers it reduced risk by roughly 90 percent, and by 95 percent in women whose ovaries had also been removed.
Does removing the healthy breast improve survival after breast cancer?
A Cochrane review found it lowers the chance of cancer in that breast but found insufficient evidence that it improves survival.
Can I keep my nipples?
In many cases, with a nipple-sparing mastectomy, when no cancer lies close to the nipple.
Can reconstruction be done at the same time?
Yes. Implants or your own tissue can be placed in the same operation, or reconstruction can wait.
How long is the recovery?
Two to four weeks for light work after mastectomy alone, longer with tissue reconstruction.
Can I ask for a female surgeon?
Yes. Mention it in your first message and the department arranges it.
References
Kuchenbaecker KB, Hopper JL, Barnes DR, et al. Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers. JAMA. 2017;317(23):2402-2416.
Rebbeck TR, Friebel T, Lynch HT, et al. Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers. The PROSE Study Group. J Clin Oncol. 2004;22(6):1055-1062.
Carbine NE, Lostumbo L, Wallace J, Ko H. Risk-reducing mastectomy for the prevention of primary breast cancer. Cochrane Database Syst Rev. 2018;4(4):CD002748.
Shaheen MS, Wan D, Momeni A. Complication rates in therapeutic versus prophylactic bilateral mastectomies. Insights from a national database. Ann Plast Surg. 2023;91(4):422-427.
ElSherif A, Cocco D, Bernard S, et al. Simultaneous contralateral prophylactic mastectomy compared to unilateral nipple-sparing mastectomy for breast cancer surgical treatment. Are complications higher? Am J Surg. 2023;225(3):527-531.
Editor's note
Written by the Biruni Hospital medical editorial team. Reviewed by Prof. Dr. Özcan YILDIZ, Medical Oncology.